BAM15 - 30x 15 mg capsules

CAS Number: 210302-17-3

BAM15 is a novel mitochondrial uncoupler that has demonstrated a range of performance-enhancing benefits, particularly in the context of metabolic health, fat loss, and cellular function. Here's an overview of its key effects:

🔬 Mechanism of Action

BAM15 operates by dissipating the proton gradient across the mitochondrial inner membrane, a process known as mitochondrial uncoupling. This action reduces ATP production efficiency, leading to increased energy expenditure as the body compensates by burning more calories, primarily from fat stores .biologyinsights.com

⚡ Performance-Enhancing Benefits

1. Fat Loss and Body Composition

Studies have shown that BAM15 can reduce body fat without affecting lean mass. In aged mice with obesity, BAM15 administration resulted in an average 8% increase in muscle mass, a 40% improvement in strength, and more than 20% fat loss .pbrc.edu

2. Improved Glucose Metabolism

BAM15 enhances glucose uptake in skeletal muscle and increases oxygen consumption rates. It activates key energy-regulating pathways, including AMPK and AKT, and promotes the translocation of GLUT4 to the plasma membrane, thereby improving insulin sensitivity .diabetesjournals.org

3. Enhanced Energy Expenditure

By uncoupling mitochondrial respiration, BAM15 increases basal metabolic rate and thermogenesis. This leads to higher calorie burn even at rest, contributing to fat loss and improved metabolic efficiency .biologyinsights.comchrisduffin.myshopify.com

4. Antioxidant and Anti-Inflammatory Effects

BAM15 treatment has been associated with increased antioxidant capacity, as evidenced by an improved GSH:GSSG ratio and decreased levels of oxidized lipids and pro-inflammatory eicosanoids. These effects may help mitigate oxidative stress and inflammation, which are linked to aging and metabolic diseases .pmc.ncbi.nlm.nih.gov

5. Potential Longevity Benefits

In animal models, BAM15 has been shown to enhance longevity, improve locomotor function, and upregulate genes related to mitochondrial function and antioxidant defense, suggesting potential benefits for aging and mitochondrial health .onlinelibrary.wiley.com

6. Selective Targeting of Visceral Fat

BAM15 has a preferential effect on visceral fat, the deep abdominal fat associated with metabolic syndrome and cardiovascular risk, making it a promising candidate for targeted fat loss strategies .chrisduffin.myshopify.com

⚠️ Safety and Tolerability

Unlike some earlier uncouplers, BAM15 does not cause plasma membrane depolarization, reducing the risk of off-target effects and cytotoxicity. It has demonstrated low toxicity in vitro and in vivo, with no significant adverse effects observed at effective doses .pmc.ncbi.nlm.nih.gov+3pubmed.ncbi.nlm.nih.gov+3pubs.acs.org+3pmc.ncbi.nlm.nih.gov+1pubs.acs.org+1

🧠 Summary

BAM15 represents a promising approach to enhancing metabolic performance through mitochondrial uncoupling. Its ability to increase energy expenditure, improve glucose metabolism, reduce body fat, and potentially extend lifespan positions it as a valuable tool in the management of obesity, insulin resistance, and aging-related metabolic decline. However, further clinical studies are necessary to fully understand its efficacy and safety in humans.

⚠️ Disclaimer: This compound is offered for laboratory research purposes only. It is not approved for medical, clinical, or diagnostic use in humans or animals. Therefore, if your lab is conducting experiments involving mitochondrial dynamics, redox regulation, or neuroprotection, buy Methylene Blue for research today from Kimera Chems.